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FZD6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA132780

Catalog No. PA132780


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Description

Description

PA1-32780 detects Frizzled 6 from human samples. PA1-32780 has been successfully used in immunocytochemistry, immunohistochemistry (paraffin tissue) applications. The PA1-32780 immunogen is: Synthetic peptide, KLH conjugated. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

This gene represents a member of the  ft.frizzled ft. gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
Specifications

Specifications

FZD6
Polyclonal
Unconjugated
FZD6
Liquid
FZD6
Synthetic peptide, KLH conjugated.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 0.01% sodium azide; pH 7.7
O60353
FZ6, HFZ6
Rabbit
IgG
25 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8323
Documents
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