FTO Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520736
A suggested positive control is human uterus tissue lysate. PA5-20736 can be used with blocking peptide PEP-0850.Rising obesity rates are rapidly becoming a growing health concern in the developing world. The fat mass and obesity associated gene (FTO) is the first gene discovered to contribute to common forms of human obesity. FTO is a member of the non-heme dioxygenase superfamily, encoding a 2-oxoglutarate-dependent nucleic acid demethylase whose mRNA is widely expressed, especially in neurons of feeding-related nuclei of the brain. FTO mRNA in the arcuate nucleus in mice is up-regulated by feeding and down-regulated during fasting, although the opposite pattern has been observed in rats. At least four isoforms of FTO are known to exist.
|A 15 amino acid peptide from near the amino terminus of human FTO.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity-associated protein; protein fto|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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