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FXR2 Mouse, Unlabeled, Clone: 55, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611330

Catalog No. BDB611330


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Description

Description

The fragile X syndrome results from amplification of a polymorphic CGG repeat in the 5 ft. untranslated region of the FMR1 gene and is the most common form of inherited mental retardation. Although the lack of expression of FMR1 protein produces the fragile X syndrome, the pathological mechanism is not known. FMR1 is an RNA binding protein that performs a chaperone or transporter function. It interacts with FXR1 and FXR2. These proteins have 60% identity with FMR1 and have similar KH and RNA binding domains. All three proteins are
cytosolic, associate with the 60S ribosomal subunit, and form homomers or heteromers with each other. During embryonic development, FMR1, FXR1, and FXR2 are expressed primarily in the nervous system. Small amounts of FMR1, FXR1, and FXR2 shuttle between the cytoplasm and nucleus. FMR1 is found in the nucleoplasm, while FXR2 is localized to the nucleolus. Thus, FMR1, FXR1, and FXR2, either individually or in tandem, function to transport RNAs throughout the cytoplasm and to specific sites in the nucleus. Alterations in the interactions between these proteins and ribosomal components may underlie the pathology that produces fragile X syndrome.

Host Species: Mouse
Clone: 55
Isotype: IgG2b
Species Reactivity: Rat
Immunogen: Human FXR2 aa. 520-639
Formula Weight [Chemical]: 95kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

FXR2
55
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2b
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Fragile X
Affinity Purified
Human FXR2 aa. 520-639
50μg
Cell Biology
Primary
Human, Rat
Documents
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