Fyn, clone: 1S, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112607
Fyn is a membrane-associated non-receptor protein tyrosine kinase that belongs to the Src-family of kinases. The unique N-terminal domain of Fyn interacts with the CD3 and Delta chains of the TcR. p59 fyn can bind other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of Fyn activity. Fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.MA1-12607 detects Fyn in human, mouse and rat samples.MA1-12607 has been successfully used in Western blot and immunohistochemistry procedures. Positive control of human or mouse T cell hyridomas, jurkat cells or T cells in tonsil suggested. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer pH 6.0 for 10-20 minutes followed by cooling at RT for 20 min. The MA1-12607 immunogen is a recombinant protein corresponding to residues 1-206 of mouse p59fyn.
|PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4|
|P06241, P39688, Q62844|
|-20° C, Avoid Freeze/Thaw Cycles, Avoid Freeze/Thaw Cycles|
|14360, 25150, 2534|
|Immunohistochemistry (Paraffin), Western Blot|
|Recombinant protein corresponding to residues 1-206 of murine p59fyn.|
|Human, Murine, Rat|
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