Fyn (pY528)/c-Src (pY530) Mouse, Unlabeled, Clone: 31, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612668
p59fyn is a member of the Src family of protein tyrosine kinases. Two isoforms of the protein have been identified, designated as FynB and Fyn T. Fyn B has been shown to be localized to the brain, whereas Fyn T associates with both B and T cells. Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. p59fyn kinase (Fyn T) associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59fyn in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. p59fyn kinase is tyrosine phosphorylated at two sites, Tyr-417 (autophosphorylation site), and Tyr-528 (negative regulatory site).
Intracellular Staining, Western Blotting
|Fyn (pY528)/c-Src (pY530)|
|Phosphorylated Human Fyn (Y528) Peptide|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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