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TGR5, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523149

Catalog No. PIPA523149

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

GRP19 (BG37, TGR5) is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing GPR19 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues.

Specifications

Specifications

TGR5/GPBAR1
Polyclonal
Unconjugated
GPBAR1
Purified
GPBAR1
Synthetic peptide (302 LWGRASRDSPGPSIAYHPSSQ 322) of G Protein-Coupled Receptor TGR5 protein.
Antigen affinity chromatography
Store at -20°C, Avoid Freeze/Thaw Cycles
Primary
151306
Immunohistochemistry (Paraffin), Western Blot
0.5mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8TDU6
G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37
Rabbit
IgG
100μg
Antibody
Polyclonal
Human
Documents
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