TGR5, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523149
GRP19 (BG37, TGR5) is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing GPR19 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues.
|Synthetic peptide (302 LWGRASRDSPGPSIAYHPSSQ 322) of G Protein-Coupled Receptor TGR5 protein.|
|Antigen affinity chromatography|
|Store at -20°C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok