GPR35 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523237
DescriptionGPR35 initially identified as an orphan G-protein coupled receptor, was recently deorphanized using high-throughput intracellular calcium measurements in clonal cell lines expressing a chimeric G-protein alpha-subunit. Recent studies confirm kynurenic acid, a tryptophan metabolite, as a ligand for GPR35. The protein shares homology with purinergic P2Y receptors, lysophosphatidic acid receptor GPR23, nicotinic acid receptor HM74, and the cannabinoid receptor GPR55. Expression analysis revealed prominent expression of the protein in immune and gastrointestinal tissues, suggesting potential physiological roles for GPR35 in these organs. The potential role of the protein involves regulating neuronal excitability and synaptic release. The protein has also been reported as a potential oncogene implicated in gastric cancer. The gene encoding for human GPR35 is localized in the chromosomal region 2q37.3.
|Synthetic peptide (291 VAPSAKAHKSQDSLC 305) of G Protein-Coupled Receptor GPR35 protein.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|G-protein coupled receptor 35, KYNA receptor, kynurenic acid receptor|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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