Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

GABRG2 Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen OPA104110

Catalog No. OPA104110

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine, chicken, canine, human, mouse and non-human primate based on 100% sequence homology. In Western blot, this antibody detects a 44-46 kDa protein representing GABA-A receptor subunit gamma 2 from rat brain fractions.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA A-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
Specifications

Specifications

GABRG2
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P18508
Gamma aminobutyric acid (GABA) A receptor gamma 2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29709
Dot Blot, Western Blot
Unconjugated
Gabrg2
Liquid
GABRG2
Fusion protein from the cytoplasmic loop of the gamma 2 subunit of rat GABRG2
Affinity chromatography
RUO
Antibody
Polyclonal
Rat
SDS
Documents
Product Certifications
Promotions

Promotions

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit