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GAD65/GAD67 Rabbit anti-Feline, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA184572

Catalog No. PA184572


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Description

Description

A suggested positive control for immunohistochemical applications is brain. In Western blot, a doublet at ~65/67 kDa has been observed. Rabbit anti Glutamate Decarboxylase 1/2 antibody recognizes both molecular forms of glutamate decarboxylase, GAD1 (GAD67) and GAD2 (GAD65), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predomit 67-kD form and a less-frequent 25-kD form.
Specifications

Specifications

GAD65/GAD67
Polyclonal
PBS with 0.09% sodium azide
P14748, Q05329, Q99259, P48318, P48320, P18088, Q05683
GAD1, GAD2, FLJ45882, GAD, SCP, Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform
Rabbit
IgG
100 μL
4°C or -20°C if preferred
Primary
101082244, 14415, 14417, 24379, 24380, 2571, 2572, 493699
ELISA, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Unconjugated
GAD2
Liquid
GAD1, GAD2
Synthetic peptide sequence DFLIEEIERLGQDL from the C-terminus of GAD.
Protein A
RUO
Antibody
Polyclonal
Feline, Human, Mouse, Rat
Documents
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