GAD67 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141138
The sequence used is 100% homologous with mouse and 94% homologous with rat GaD67. Suggested positive control: antigen standard for GAD1 (transient overexpression lysate), SK-N-SH.GAD67, a 67KDa protein, is a neuronal isoform of this enzyme predomitly expressed in human Brain. It consists of Pyridoxal 5’-phosphate binding site and conserved Cysteine residues which are vital for its activity and is inhibited due to phosphorylation. It has high binding affinity for the cofactor Pyridoxal-5’phosphate and its role has been implicated in normal Palate development. It is found to be associated with childhood onset schizophrenia and craniofacial malformations and has been identified as a major auto antigen and an auto-reactive T-cell target in IDDM. Deficiency of this enzyme leads to pyridoxine dependency along with epilepsy. It also might play a role in stiff main syndrome.
|Synthetic peptide, KLH-conjugated, corresponding to a portion of amino acids 1-100 of human GaD67.|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Glutamic acid decarboxylase 67|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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