Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Galectin 3 Mouse anti-Human, Mouse, Clone: B2C10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140229

Catalog No. 01-676-569


Add to cart

Description

Description

MA1-40229 detects Galectin-3 from human and mouse samples. This antibody does not cross react with Galedin-3C and is cross reactive with mouse galectin-3. MA1-40229 has been successfully used in flow cytometry, immunohistochemistry (frozen), immunohistochemistry (paraffin), functional assays, ELISA and Western blot applications. The MA1-40229 immunogen is the first 45 residues of human Galectin-3. Endotoxin <24 EU/mg. Positive control: Huvec cells

Galectin-3 is a member of the galectin family and is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of maligcies, such as colon, breast, ovarian and uterine carcinomas. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions.
Specifications

Specifications

Galectin 3
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
P17931, P16110
LGALS3
Mouse
IgG1
100 μg
4° C
Primary
16854, 3958
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
B2C10
Unconjugated
LGALS3
Liquid
LGALS3
First 45 residues of human Galectin-3.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
Promotions

Promotions

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit