Gap1(m) Mouse, Unlabeled, Clone: 15, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610730
The biological activity of Ras is mediated by the conversion of bound GTP to DP. This process is controlled, in part, by Ras guanine nucleotide releasing factor (GNRP) and several Ras GTPase-activating proteins (GAPs). p120GAP is the GTPase for the normal form of Ras, but is not reactive with oncogenic Ras. Gap1[m] is a homologue of the Drosophila Gap1 protein which also affects the non-oncogenic form of Ras. Gap1[m] is a 100kDa protein GTPase that binds Ras with high affinity and, unlike p120GAP, Gap1[m] contains no SH2 or SH3
domains. At its N-terminus, Gap1[m] has two repeats similar to the C2 domain of Protein Kinase C. The GAP-related domain (GRD) is centrally located and is flanked on the C-terminal side by a pleckstrin homology domain.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Human, Murine, Rat|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|Rat Gap1[m] aa. 20-200|
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