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GAPDH Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1987

Catalog No. PA1987


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Description

Description

PA1-987 detects rat GAPDH. Shares 100% sequence homology with human and mouse. PA1-987 has been used successfully in Western blotting. By Western blot this antibody specifically detects a ~36 kDa protein representing GAPDH. PA1-987 immunizing peptide corresponds to amino acid residues 126-140 from human GAPDH.

GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer ft.s disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington ft.s disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.
Specifications

Specifications

GAPDH
Polyclonal
Unconjugated
GAPDH
Liquid
GAPDH
Synthetic peptide: V(126) M G V N H E K Y(140)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Non-human primate, Rat
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q28259, P04406, P16858, P04797
Glyceraldehyde-3-Phosphate Dehydrogenase, GAPD, G3PD, G3PDH
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14433, 24383, 2597, 403755
Documents
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