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CNGB1 Rabbit anti-Bovine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1728

Catalog No. PA1728

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity.To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.

PA1-728 detects glutamic acid rich protein2 (GARP2) protein in rat and bovine samples.PA1-728 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~60kDa protein representing GARP2 from rat purified rod outer membranes. The PA1-728 immunogen is a synthetic peptide corresponding to residues C(287) D V Q T R V V A A G S L(299) of bovine GARP2. This immunizing peptide (PEP-247) can be used for neutralization and control experiments.
Specifications

Specifications

CNGB1
Polyclonal
Unconjugated
Cngb1
Liquid
CNGB1
Synthetic peptide corresponding to residues C(287) D V Q T R V V A A G S L(299) of bovine GARP2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Rat
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q28181
Glutamic Acid-Rich Protein-2
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
281702, 83686
Documents
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