CNGB1 Rabbit anti-Bovine, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1728
Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity.To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.PA1-728 detects glutamic acid rich protein2 (GARP2) protein in rat and bovine samples.PA1-728 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~60kDa protein representing GARP2 from rat purified rod outer membranes. The PA1-728 immunogen is a synthetic peptide corresponding to residues C(287) D V Q T R V V A A G S L(299) of bovine GARP2. This immunizing peptide (PEP-247) can be used for neutralization and control experiments.
|Synthetic peptide corresponding to residues C(287) D V Q T R V V A A G S L(299) of bovine GARP2.|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Glutamic Acid-Rich Protein-2|
|-20° C, Avoid Freeze/Thaw Cycles|
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