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GBL Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA515511

Catalog No. PIPA515511

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

G-protein beta subunit like (GBL protein) is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin-receptor activation including insulin-stimulated glucose transport and glycogen synthesis. Northern Blot analysis detected a ubiquitous expression of LST8 with highest expression in brain and testis.
Specifications

Specifications

GBL
Polyclonal
PBS with 0.09% sodium azide
Q9BVC4
G protein beta subunit-like; GBL protein; GBL;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
64223
Immunohistochemistry, Western Blot
Unconjugated
MLST8
Liquid
MLST8
KLH conjugated synthetic peptide between 140-170 amino acids from the central region of human GBL
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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