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GBP1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523509

Catalog No. PIPA523509


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Description

Description

GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
Specifications

Specifications

GBP1
Polyclonal
PBS with 0.05% BSA and 0.05% sodium azide
P32455, Q01514
GBP-1, GTP-binding protein 1, guanine nucleotide-binding protein 1, guanylate binding protein 1, interferon-inducible, 67kDa, huGBP-1, interferon-induced guanylate-binding protein 1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
14468, 2633
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
GBP1
Liquid
GBP1, Gbp2b
Synthetic peptide (521 ERSYQEHLKQLTEKMENDR 539) of GBP1 protein.
Protein A
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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