Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

GCIP Mouse, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612294

Catalog No. BDB612294


Add to cart

Description

Description

Adaptor proteins are critical for the formation of signaling complexes that relay signals from the plasma membrane to the nucleus. These proteins are involved in diverse pathways that regulate cell growth, differentiation, and death. GCIP (Grap2 Cyclin-D Interacting Protein) was identified in a yeast two-hybrid screen where the leukocyte-specifc adaptor protein Grap2 was used as bait. The sequence of GCIP is 65% homologous to mouse Maid, a negative regulator of transcription factors in mouse egg and zygote. GCIP protein contains a DNA binding HLH domain and a leuzine-zipper-like motif. GCIP mRNA is widely expressed in most tissues with higher expression in heart, muscle, leukocytes, kidney, and brain. Similar to Grap2, GCIP binds cyclin-D1 and the novel protein p29 GCIP interacting protein. Transfection of GCIP in cells reduces phosphorylation of Rb by cyclin-D-interacting protein kinase and inhibited E2F1-mediated transcriptional activity. Thus, GCIP may function as an adaptor protein that may regulate gene expression important for cell cycle regulation and immune signaling.

Western Blotting

Specifications

Specifications

GCIP
54
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Grap2 Cyclin-D Interacting Protein
Affinity Purified
Human GCIP aa. 62-277
50μg
Cell Biology
Primary
Canine, Human, Murine, Rat
SDS
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit