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GCK Rabbit anti-Human, Rat, Polyclonal, Invitrogen

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA515072

Catalog No. PIPA515072


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Description

Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2); mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Specifications

Specifications

GCK
Polyclonal
Unconjugated
GCK
Liquid
GCK
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCK
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 0.09% sodium azide
P17712, P35557
Hexokinase D; Hexokinase type IV; HK IV; HK4; Glucokinase
Rabbit
IgG
200μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2645, 24385
Documents
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