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GFAP Mouse anti-Human, Mouse, Clone: 6F2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA135377

Catalog No. 01-671-432


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Description

Description

In Western blot, only the 56kDa GFAP band is detected when performed on crude brain extract.

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily, and specifically, expressed in astrocytes and certain astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Specifications

Specifications

GFAP
Monoclonal
Unconjugated
GFAP
Liquid
GFAP
GFAP from human brain.
1 mL
4° C
Primary
14580, 2670
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
6F2
tissue culture supernatant with 0.09% sodium azide
P14136, P03995
GFAP
Mouse
IgG1
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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