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GFAP Mouse anti-Human, Alexa Fluor® 488, Clone: 131-17719, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A21294

Catalog No. A21294


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Description

Description

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily, and specifically, expressed in astrocytes and certain astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

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Specifications

Specifications

GFAP
Monoclonal
1 mg/mL
PBS with 0.1% BSA and 5mM sodium azide; pH 7.2
P14136
Glial fibrillary acidic protein, GFAP, GFAP
Mouse
IgG1, kappa
50 μL
4° C, store in dark
Primary
2670
Immunocytochemistry, Immunofluorescence
131-17719
Alexa Fluor™ 488
GFAP
Liquid
GFAP
protein glial fibrillary acidic protein
Purified
RUO
Antibody
Monoclonal
Human
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