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GFAP Rabbit anti-Bovine, Equine, Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA110019

Catalog No. 01-670-276


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Description

Description

By Western blot, two bands are detected in rat cerebellum homogenate: a prominent band at 50kDa corresponding to rodent GFAP and a lower band at ~45kDa that most likely represents a proteolytic fragment derived from the GFAP molecule.

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily, and specifically, expressed in astrocytes and certain astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Specifications

Specifications

GFAP
Polyclonal
whole serum with no preservative
Q28115, P14136, P03995, P47819
GFAP, FLJ45472
Rabbit
IgG
RUO
Antibody
Polyclonal
Bovine, Equine, Human, Mouse, Porcine, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
GFAP
Liquid
GFAP
Full-length recombit human GFAP protein
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100033970, 14580, 24387, 2670, 281189, 396562
Documents
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