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GFAP Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA19565

Catalog No. 01-674-441


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Description

Description

PA1-9565 detects GFAP in human, mouse and rat samples. PA1-9565 has been successfully used in Western blot, immunohistochemistry, and immunocytochemistry procedures. The PA1-9565 immunogen is a human GFAP fusion protein.

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily, and specifically, expressed in astrocytes and certain astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Specifications

Specifications

GFAP
Polyclonal
Unconjugated
GFAP
Liquid
GFAP
Human GFAP fusion protein
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunohistochemistry, Western Blot
1 mg/mL
PBS with no preservative
P14136, P03995, P47819
GFAP, FLJ45472
Rabbit
IgG
50 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14580, 24387, 2670
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