GFR alpha-2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112804
A suggested positive control for this product is HeLa cell lysate.Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNR&No.945;, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNR&No.945; was also termed GDNFR&No.946;, Ret ligand 2 (RETL2) or TGF&No.946;-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR&No.945;-2 recently. GFR&No.945;-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR&No.945;-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
|PBS with 0.02% sodium azide|
|GDNF family receptor alpha-2, GFR-alpha-2, Neurturin receptor alpha, NTNR-alpha, NRTNR-alpha, TGF-beta-related neurotrophic factor receptor 2, GDNF re|
|-20° C, Avoid Freeze/Thaw Cycles|
|14586, 25136, 2675|
|Synthetic peptide corresponding to residues 377-391 of human GFRalpha.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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