GFR alpha-2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112804
A suggested positive control for this product is HeLa cell lysate.Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNR&No.945;, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNR&No.945; was also termed GDNFR&No.946;, Ret ligand 2 (RETL2) or TGF&No.946;-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR&No.945;-2 recently. GFR&No.945;-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR&No.945;-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
|PBS with 0.02% sodium azide|
|GDNF family receptor alpha-2, GFR-alpha-2, Neurturin receptor alpha, NTNR-alpha, NRTNR-alpha, TGF-beta-related neurotrophic factor receptor 2, GDNF re|
|-20° C, Avoid Freeze/Thaw Cycles|
|14586, 25136, 2675|
|Synthetic peptide corresponding to residues 377-391 of human GFRalpha.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok