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GGPS1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512167

Catalog No. PIPA512167

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine and rat based on sequence homology.

Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombit GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.
Specifications

Specifications

GGPS1
Polyclonal
PBS with 0.09% sodium azide
O95749, Q9WTN0
Geranylgeranyl pyrophosphate synthetase; GGPP synthetase; GGPPSASE; Geranylgeranyl diphosphate synthase
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14593, 9453
Immunohistochemistry, Western Blot
Unconjugated
GGPS1
Liquid
GGPS1
KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human GGPS1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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