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G protein-coupled receptor kinase interacting ArfGAP 2 (A02), Mouse anti-Human, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a partial recombinant GIT2.

Manufacturer:  Abnova Corporation H00009815A02

Catalog No. 89-004-452


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Description

Description

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq

Sequence: TDLETTASKTNRQKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHA
Specifications

Specifications

G protein-coupled receptor kinase interacting ArfGAP 2
Unconjugated
50% glycerol
NM_014776
CAT-2|DKFZp686G01261|KIAA0148|MGC760
Mouse
50 uL
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Primary
9815
ELISA, Western Blot
Mouse polyclonal antibody raised against a partial recombinant GIT2.
GIT2
Serum
GIT2
GIT2 (NP_055591, 401 a.a. ~ 498 a.a) partial recombinant protein with GST tag.
RUO
Y
Polyclonal
Human
Documents
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