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GITR Ligand Rat anti-Mouse, Brilliant Violet 421, Clone: MIH44, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 563366

Catalog No. BDB563366


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Description

Description

The MIH44 monoclonal antibody specifically binds to Glucocorticoid-induced TNF-related Ligand (GITR Ligand). The GITR Ligand protein is encoded by the Tnfsf18 ( Tumor necrosis factor ligand superfamily member 18 ) gene. The GITR Ligand is a type II transmembrane protein that is expressed on endothelial cells and antigen presenting cells, including B cells, macrophage and dendritic cells. The GITR Ligand reportedly costimulates T cell activation and reverses CD4+CD25+ Treg cell-mediated suppression by interaction with its cognate receptor, GITR that is expressed by these cells.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.

Specifications

Specifications

GITR Ligand
MIH44
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Rat
IgG2b, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Tnfsf18; Gitrl;Glucocorticoid-induced-tumor necrosis factor receptor ligand
Affinity Purified
GITRL/GFP-transfected L cells
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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