GLE1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520660
A suggested positive control is mouse brain tissue lysate. PA5-20660 can be used with blocking peptide PEP-0780.The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
|A 15 amino acid peptide near the carboxy terminus of human Gle1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q53GS7, Q8R322, Q4KLN4|
|GLE1L, LCCS, LCCS1, hGLE1; GLE1-like protein; GLE1-like, RNA export mediator; nucleoporin GLE1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|2733, 362098, 74412|
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