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GLE1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520660

Catalog No. PIPA520660


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Description

Description

A suggested positive control is mouse brain tissue lysate. PA5-20660 can be used with blocking peptide PEP-0780.

The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
Specifications

Specifications

Gle1
Polyclonal
Unconjugated
GLE1
Liquid
GLE1
A 15 amino acid peptide near the carboxy terminus of human Gle1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q53GS7, Q8R322, Q4KLN4
GLE1L, LCCS, LCCS1, hGLE1; GLE1-like protein; GLE1-like, RNA export mediator; nucleoporin GLE1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
2733, 362098, 74412
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