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GLS2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521113

Catalog No. PIPA521113


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Description

Description

A suggested positive control is rat kidney tissue lysate. PA5-21113 can be used with blocking peptide PEP-1227.

Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53’s role in antioxidant defense in addition to its role in energy metabolism.
Specifications

Specifications

GLS2
Polyclonal
Unconjugated
GLS2
Liquid
GLS2
An 18 amino acid peptide near the center terminus of human GLS2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UI32, Q571F8, P28492
GA, GLS, LGA, hLGA; L-glutaminase; L-glutamine amidohydrolase; breast cell glutaminase; glutaminase GA; glutaminase I; glutaminase liver isoform, mitochondrial; phosphate-activated glutaminase; phosphate-dependent glutaminase
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
192268, 216456, 27165
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