GluR δ2 Mouse, Unlabeled, Clone: 48, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611006
Glutamate is a major excitatory neurotransmitter of the CNS. The diversity of glutamate is exemplified by two distinct groups of receptors: ionotropic and metabotropic. Ionotroic receptors are ligand-gated cation channels. They can be subdivided into two classes: NMDA and AMPA/kainate receptors. GluR δ2 exhibits only 25% amino acid identity to either ionotropic receptor type. It presents selective and abundant exression in cerebellar Purkinje cells. It is targeted to a subset of Purkinje cell spines and is coexpressed with ionotropic receptors. GluR δ2 is involved in motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression (LTD). The latter is a decrease in the efficacy of the synaptic transmission between parallel fibers and Purkinje neurons and is a cellular basis of motor learning. In fact, mGluR δ2-deficient mice lack LTD. Additionally, an amino acid substitution in transmembrane III of δ2 is responsible for the neurodegeneration seen in Lurcher mice. This substitution is a gain of function mutation that results in disruption of Purkinje membrane potential. Thus, GluR δ2 is an important regulatory component of the Purkinje GluR channel.
Immunofluorescence, Western Blotting
|Mouse GluR δ2 aa. 665-786|
|Murine, Rabbit, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok