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mGluR5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA138132

Catalog No. 01-673-681


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Description

Description

This antibody is predicted to react with bovine, canine, amphibian, mouse, rabbit and rat based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is brain tissue.

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
Specifications

Specifications

mGluR5
Polyclonal
PBS with 1% BSA and <0.1% sodium azide; pH 7.6
P41594
GPRC1E, MGLUR5, mGlu5, metabotropic glutamate receptor 5, metabotropic glutamate receptor 5 variant F, metabotropic glutamate receptor 5 variant G, metabotropic glutamate receptor 5 variant H
Rabbit
IgG
1 mL
4° C, do not freeze
Primary
2915
Immunohistochemistry (Paraffin)
Unconjugated
GRM5
Liquid
GRM5
Synthetic peptide from C-terminus of human mGluR5.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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