Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-GLUT-4, C-terminus, Polyclonal, ™ (Upstate™) Non-distribution product as customer accommodation.

Manufacturer:  MilliporeSigma™ 071404/DEL

Catalog No. 50-172-250

This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
View substitute products »


Description

Description

GLUTs (Glucose transporters) are a family of integral membrane proteins that facilitative glucose uptake by cells. They are integral membrane glycoproteins involved in transporting glucose into most cells. Seven types of glucose transport carrier proteins, designated as GLUT 1 to 7, facilitate glucose transport across the cell membrane. Molecular cloning of glucose transporters have identified a family of closely related genes that encode at least 7 proteins exhibiting high degree of amino acid homology (45% to 65%), all in the molecular weight range of 40 to 60kd. GLUT-1 functions in constitutive or basal glucose uptake in adult tissues and is the predominant glucose transporter in embryonic and fetal tissues. It has two forms, a 55kd and a 45kd. The 55kd form of GLUT1 regulates import of glucose from blood to brain across the endothelial cells of the blood-brain barrier (BBB), whereas the 45kd form of GLUT1 predominantly regulates nonvascular glial glucose uptake. GLUT2 is a facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. GLUT-4 is present in skeletal muscle, heart and adipose tissues. GLUT-4 is highly conserved between species. The expression of GLUT-4 is greatly influenced by insulin and other stimulators of the IP3 signaling pathway. Binding of insulin to the insulin receptor signals through PI3K and Akt to translocate GLUT-4 to the plasma membrane where it allows the uptake of glucose.

Host Species:Rabbit
Clone:
Isotype:IgG
Species Reactivity:Human, Bovine, Rat, Mouse, Porcine
Epitope:C-terminus
Immunogen:Synthetic peptide corresponding to the C-terminus (amino acids 498-510) of mouse GLUT-4.
Molecular Weight:Identifies a major band at ~55kDa.

ELISA, Immunohistochemistry (Paraffin), Western Blotting

Specifications

Specifications

GLUT-4, C-terminus
Affinity Purified
IgG
RUO
Primary
Bovine, Human, Murine, Porcine, Rat
Unconjugated
Rabbit
100μL
Cell Signaling
Polyclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit