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Glutamine Synthetase, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA126786

Catalog No. PIPA126786

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Glutamine Synthetase (GS) catalyzes the conversion of ammonia and glutamate to glutamine. This reaction consumes a molecule of ATP: Glutamate + NH4+ + ATP = Glutamine + ADP + Pi. GS is found in astrocytes as an octamer of identical ~45kDa subunits. Most well known function of GS is the detoxification of brain ammonia. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. On the other hands, the level of expression of GS is increased during ischemia in vivo or hypoxia in culture.

PA1-26786 detects Glutamine Synthetase from E. coli samples.PA1-26786 has been successfully used in immunoprecipitation, ELISA and Western blot procedures.The PA1-26786 immunogen is Microbial Glutamine Synthetase.Store at 4ºC short term. For extended storage, aliquot and store at -20ºC or below. Avoid freeze/thaw cycles.


Glutamine Synthetase
whole serum diluted in 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
GLNS, GLUL, Glutamine Synthase, GS, Glutamate decarboxylase, Glutamate ammonia ligase
Microbial Glutamine Synthetase.
Store at -20°C
ELISA, Immunoprecipitation, Western Blot
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