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GPX3 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118280

Catalog No. 01-670-533


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Description

Description

PA1-18280 detects Glutathione Peroxidase 3 from human and rat samples. PA1-18280 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18280 immunogen is a synthetic peptide corresponding to residues F(135) E K G D V N G E K E Q K F Y T F L K N(154) of human glutathione peroxidase 3 (GPx-P), conjugated to diphtheria toxin. The peptide is homologous with the corresponding sequence derived from glutathione peroxidase 3 (GPx-P) protein in mouse, rat, orangutan, and bovine. Reconstitute with 100 µL of distilled water.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract (1). Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation (2). Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine (3). All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).
Specifications

Specifications

GPX3
Polyclonal
whole serum with no preservative
P22352, P23764
GPx-P, GPX3
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry
Unconjugated
GPX3
Lyophilized
GPX3
Synthetic peptide corresponding to residues F(135) E K G D V N G E K E Q K F Y T F L K N(154) of human glutathione peroxidase 3 (GPx-P) conjugated to diptheria toxin.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2878, 64317
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