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GPX4 Mouse anti-Human, Clone: 7A4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen LFMA0059

Catalog No. AML0059


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Description

Description

A suggested positive control for this product is HL-60 cells.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.
Specifications

Specifications

GPX4
Monoclonal
Unconjugated
GPX4
Liquid
GPX4
Purified, recombit, human glutathione peroxidase 4 protein expressed in E. coli.
Ammonium sulfate precipitation
RUO
Antibody
Monoclonal
Human
ELISA, Immunoprecipitation
7A4
HEPES with 0.01% BSA, 0.15M NaCl, 50% glycerol and 0.03% sodium azide
P36969
GPX4, Phospholipid hydroperoxide glutathione peroxidase
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2879
SDS
Documents
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