GLRA1 Monoclonal Antibody (4D6), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA518977

Catalog No. PIMA518977

Description

Peptide Sequence: IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.

Specifications

• Antigen: GLRA1
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P23415
• Gene Symbols: GLRA1
• Immunogen: GLRA1 (NP_000162, 121 a.a. ∽ 220 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 4D6
• Conjugate: Unconjugated
• Gene: GLRA1
• Gene Alias: GLRA1, Glra2, GLYRA1, Glycine receptor subunit alpha-1, Glycine receptor subunit alpha-2
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2741
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid