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GLRA1 Mouse anti-Human, Clone: 4D6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA518977

Catalog No. PIMA518977


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Description

Description

Peptide Sequence: IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
Specifications

Specifications

GLRA1
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
P23415
GLRA1, Glra2, GLYRA1, Glycine receptor subunit alpha-1, Glycine receptor subunit alpha-2
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2741
ELISA, Western Blot
4D6
Unconjugated
GLRA1
Liquid
GLRA1
GLRA1 (NP_000162, 121 a.a. ∽ 220 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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