GLRA1 Mouse anti-Human, Clone: 4D6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA518977
Peptide Sequence: IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEEGLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
|PBS with no preservative; pH 7.4|
|GLRA1, Glra2, GLYRA1, Glycine receptor subunit alpha-1, Glycine receptor subunit alpha-2|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|GLRA1 (NP_000162, 121 a.a. ∽ 220 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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