P-Glycoprotein Mouse anti-Hamster, Human, Clone: JSB-1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA135604
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.This antibody reacts with a conserved cytoplasmic epitope of the plasma membrane-associated 170-180 kD glycoprotein, the expression of which is strongly correlated with the degree of multi-drug-resistance (MDR) derived cell lines, including cell lines derived from lung, ovaries and B cell lymphomas. This product cross-reacts with chinese hamster but does not cross-react with mouse or rat.
|tissue culture supernatant with 1% BSA and 0.1% sodium azide|
|ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1, CD243|
|Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|Multidrug-resistant Chinese hamster ovary cell line (CHrC5).|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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