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GM-CSF Mouse anti-Human, Clone: 6804, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523699

Catalog No. PIMA523699


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Description

Description

In ELISAs, this antibody does not cross-react with recombit mouse (rm) GM-CSF, rrGM-CSF, rhM&No.8209;CSF, rhG-CSF, rhIL-5-R alpha, or rhIL-3 R alpha. Reconstitute at 0.5 mg/mL in sterile PBS.

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombit GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
Specifications

Specifications

GM-CSF
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P04141
Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, CSF, Molgramostin, Sargramostim, CSF2, GMCSF
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1437
ELISA, Flow Cytometry
6804
Unconjugated
CSF2
Lyophilized
CSF2
E. coli-derived recombit human GM-CSF Ala18-Glu144
Protein A/G
RUO
Antibody
Monoclonal
Human
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