GnRHR Mouse anti-Human, Clone: A9E4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA135383
The immunogen corresponds to amino acid sequence 1(MANSASPEQNQHCSAINNSIPLMQGNLPY)29 of the human GnRH receptor extracellular domain.This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 ft. region and multiple polyA signals in the 3 ft. region have been identified for this gene.
|PBS with 0.02% sodium azide|
|ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot|
|Human GnRH receptor extracellular domain (residues 1-29) peptide conjugated to BSA.|
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