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GP6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525597

Catalog No. PIPA525597


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Description

Description

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
Specifications

Specifications

GP6
Polyclonal
PBS with 0.09% sodium azide
Q9HCN6
BDPLT11, GPIV, GPVI, glycoprotein 6, platelet collagen receptor, platelet glycoprotein VI
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51206
Flow Cytometry, Western Blot
Unconjugated
GP6
Liquid
GP6
KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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