RNF128 Rabbit anti-Canine, Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523164
DescriptionGRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.
|Synthetic peptide (227 IFYSARRLRNARAQSRKQRQLKADAKK 253) of GRAIL/RNF128 protein.|
|Canine, Equine, Human, Mouse, Non-human primate, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|RP11-150F24.1, GRAIL, E3 ubiquitin-protein ligase RNF128, gene related to anergy in lymphocytes protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100054821, 315911, 492051, 66889, 79589|
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