Granzyme B Mouse anti-Human, PE-CF594, Clone: GB11, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 562462

Catalog No. BDB562462

Description

Monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. Antibody was conjugated with Horizon™ PE-CF594 under optimum conditions, and unconjugated antibody and free PE-CF594 were removed. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. Granzyme B acts on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis.

Host Species: Mouse
Clone: GB11
Isotype: IgG1, κ
Species Reactivity: Human
Immunogen: Human Granzyme B

• Involved in the hydrolysis of extracellular matrix components
• PE-CF594 can be excited by the blue (488nm), green (532nm) and yellow-green (561nm) lasers and can be detected with the same filter set as PE-Texas Red

Intracellular Staining, Flow Cytometry

Specifications

• Antigen: Granzyme B
• Classification: Monoclonal
• Concentration: 5μL
• Description: GZMB; Granzyme-2; CCPI; CGL1; CSPB; CTLA1; CTSGL1; GRB; HLP; SECT
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: GB11
• Conjugate: PE-CF594
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human Granzyme B
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.