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Granzyme B Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA126616

Catalog No. PA126616


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Description

Description

PA1-26616 detects Granzyme B from human, rat, and mouse samples. PA1-26616 has been successfully used in Immunofluorescence, immunohistochemistry (frozen), and immunohistochemistry (paraffin) procedures. For IHC (paraffin) procedures perform heat mediated antigen retrieval using 10mM citrate buffer (p.H. 6.0) before commencing with the IHC staining protocol. Positive Control: Tonsil The PA1-26616 immunogen is a synthetic peptide corresponding to residues E(20) I I G G H E A K P H S R P Y M A Y L(38) of human Granzyme B.

Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
Specifications

Specifications

Granzyme B
Polyclonal
PBS with 0.1% sodium azide
P10144, P04187, P18291
GrB
Rabbit
IgG
500 μL
4° C, do not freeze
Primary
14939, 171528, 3002
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Unconjugated
GZMB
Liquid
GZMB
Synthetic peptide corresponding to residues E(20) I I G G H E A K P H S R P Y M A Y L(38) of human Granzyme B.
IgG fraction
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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