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GREM1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513123

Catalog No. PIPA513123


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Description

Description

This antibody is predicted to react with rat based on sequence homology.

GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.
Specifications

Specifications

GREM1
Polyclonal
Unconjugated
GREM1
Liquid
GREM1
KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of human GREMLIN
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
O60565, O70326
Cysteine KNOT superfamily 1, BMP antagonist 1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23892, 26585
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