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GluR7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520450

Catalog No. PIPA520450


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20450 can be used with blocking peptide PEP-0567.

Glutamate receptors are the predomit excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
Specifications

Specifications

GluR7
Polyclonal
Unconjugated
GRIK3
Liquid
GRIK3
A 13 amino acid peptide near the amino terminus of the human Grik3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q13003, B1AS29, P42264
EAA5, GLR7, GLUR7, GluR7a; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); excitatory amino acid receptor 5; gluR-7; glutamate receptor 7; glutamate receptor, ionotropic kainate 3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
14807, 2899, 298521
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