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GRIP Mouse anti-Rat, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611318

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Catalog No. BDB611318


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Description

Description

Rapid neuronal excitation within the CNS is mediated by the interactions of receptors with their respective neurotransmitters, such as glutamate. Glutamate has a diverse array of receptors that are categorized into two distinct groups: ionotropic and metabotropic. Ionotropic receptors are ligand-gated channels and can be subdivided into two classes: NMDA and AMPA receptors. AMPA receptors are composed of four homologous subunits (GluR1-4) that differentially combine to form a variety of receptor subtypes. Interactions of the subunits with
cytoplasmic proteins mediate the transmission of extracellular signals. GRIP (Glutamate Receptor Interacting Protein) specifically interacts with the C-terminus of the GluR2 subunit. GRIP lacks a catalytic domain, but contains seven PDZ domains which are motifs that mediate protein-protein interactions. Since only the fourth and fifth PDZ domains are utilized in interaction with GluR2, it is thought that the remaining PDZ domains interact with other unidentified proteins. Therefore, GRIP functions as an adaptor that links AMPA receptors to cytoskeletal and/or signaling molecules and, in turn, clusters them at the synapse.

Host Species: Mouse
Clone: 32
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat GRIP aa. 877-1067
Formula Weight [Chemical]: 130kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

GRIP
32
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
In vitro Assay, Western Blot
250μg/mL
Glutamate Receptor Interacting Protein
Affinity Purified
Rat GRIP aa. 877-1067
50μg
Cell Biology
Primary
Rat
Documents
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