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GRIP Mouse anti-Rat, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

$232.00 - $427.00

Specifications

Antigen GRIP
Isotype IgG1
Immunogen Rat GRIP aa. 877-1067
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611318
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BD Biosciences
611318
50μg
Each for $232.00
Add to cart
 
BDB611319
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BD Biosciences
611319
150μg
Each for $427.00
Add to cart
 
Description

Description

Rapid neuronal excitation within the CNS is mediated by the interactions of receptors with their respective neurotransmitters, such as glutamate. Glutamate has a diverse array of receptors that are categorized into two distinct groups: ionotropic and metabotropic. Ionotropic receptors are ligand-gated channels and can be subdivided into two classes: NMDA and AMPA receptors. AMPA receptors are composed of four homologous subunits (GluR1-4) that differentially combine to form a variety of receptor subtypes. Interactions of the subunits with
cytoplasmic proteins mediate the transmission of extracellular signals. GRIP (Glutamate Receptor Interacting Protein) specifically interacts with the C-terminus of the GluR2 subunit. GRIP lacks a catalytic domain, but contains seven PDZ domains which are motifs that mediate protein-protein interactions. Since only the fourth and fifth PDZ domains are utilized in interaction with GluR2, it is thought that the remaining PDZ domains interact with other unidentified proteins. Therefore, GRIP functions as an adaptor that links AMPA receptors to cytoskeletal and/or signaling molecules and, in turn, clusters them at the synapse.

Host Species: Mouse
Clone: 32
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat GRIP aa. 877-1067
Formula Weight [Chemical]: 130kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

GRIP
Rat GRIP aa. 877-1067
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Glutamate Receptor Interacting Protein
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
In vitro Assay, Western Blot
RUO
32
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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