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GRK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527480

Catalog No. PIPA527480


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Description

Description

PA5-27480 targets GRK2 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples. The PA5-27480 immunogen is recombit fragment corresponding to a region within amino acids 477 and 689 of Human GRK2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Specifications

Specifications

GRK2
Polyclonal
Unconjugated
GRK2
Liquid
GRK2
Recombit fragment corresponding to a region within amino acids 477 and 689 of Human GRK2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P25098, Q99MK8
BARK1, BETA-ARK1, GRK2, G-protein coupled receptor kinase 2, beta-ARK-1, beta-adrenergic receptor kinase 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
110355, 156
Documents
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