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G-CSF Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA129653

Catalog No. PIPA129653


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Description

Description

PA1-29653 detects GSF3 from mouse samples. PA1-29653 has been successfully used in ELISA, Neutralization and Western blot applications. Neutralization:To yield one-half maximal inhibition (ND50) of the biological activity of mG-CSF (0.5 ng/mL), a 0.005-0.010 µg/mL of this antibody is required. The PA1-29653 immunogen is: Highly pure (>98%) recombit mG-CSF (mouse Granulocyte Colony Stimulating Factor ). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. G-CSF is highly conserved among species and has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors, neutrophilic granulocytes and certain carcinoma cell lines. Clinical use of G-CSF has been approved for several therapeutic applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet ft.s syndrome and AIDS. Further, G-CSF has been shown to be a marker protein for different carcinomas such as bladder cancer and dysfunction of the protein has been linked to Kostmann Syndrome.
Specifications

Specifications

G-CSF
Polyclonal
Unconjugated
Csf3
Liquid
CSF3
Highly pure (>98%) recombit mG-CSF (mouse Granulocyte Colony Stimulating Factor ).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Control, ELISA, Neutralization, Western Blot
1 mg/mL
PBS with no preservative; pH 7.4
P09920
RP23-395E10.4, Csfg, G-CSF, MGI-IG
Rabbit
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
12985
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