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GSK-3β Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

$220.00 - $435.00

Specifications

Antigen GSK-3β
Isotype IgG1
Immunogen Rat GSK-3β aa. 1-160
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610202
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BD Biosciences
610202
150μg Each for $435.00
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BDB610201
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BD Biosciences
610201
50μg Each for $220.00
Add to cart
 
Description

Description

Glycogen Synthase Kinase-3β (GSK-3β) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and, thus, down-regulating the activity of muscle glycogen synthase. GSK-3β is identical to the Tau Protein Kinase 1 (TPK 1) which plays a role in the formation of the histopathological lesions of Alzheimer's disease (AD). In AD, many neurons contain intracytoplasmic neurofibrillary tangles (NFT) that are composed of ubiquitin and highly phosphorylated tau proteins, members of a family of microtubule-assocaited phosphoproteins. Phosphorylation of the tau proteins by GSK-3β converts them into paired helical filaments (PHF) which are found in NFT and degenerative neurites of senile plaques. This ability of GSK-3β to convert tau proteins to PHF has been demonstrated in vitro using primary cultures of embryonic rat hippocampal neurons.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

GSK-3β
Rat GSK-3β aa. 1-160
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
7
250μg/mL

For Research Use Only.

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