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GSK-3β Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

$280.00 - $556.00

Specifications

Antigen GSK-3β
Clone 7
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610201
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BD Biosciences
610201
50 μg
Each for $280.00
Only null left
Add to Cart
 
BDB610202
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BD Biosciences
610202
150 μg
Each for $556.00
Only null left
Add to Cart
 
Description

Description

Glycogen Synthase Kinase-3β (GSK-3β) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and, thus, down-regulating the activity of muscle glycogen synthase. GSK-3β is identical to the Tau Protein Kinase 1 (TPK 1) which plays a role in the formation of the histopathological lesions of Alzheimer's disease (AD). In AD, many neurons contain intracytoplasmic neurofibrillary tangles (NFT) that are composed of ubiquitin and highly phosphorylated tau proteins, members of a family of microtubule-assocaited phosphoproteins. Phosphorylation of the tau proteins by GSK-3β converts them into paired helical filaments (PHF) which are found in NFT and degenerative neurites of senile plaques. This ability of GSK-3β to convert tau proteins to PHF has been demonstrated in vitro using primary cultures of embryonic rat hippocampal neurons.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

GSK-3β
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
7
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Rat GSK-3β aa. 1-160
Primary
Store undiluted at -20°C.
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