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GSK3 alpha Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA125969

Catalog No. PIPA125969


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Description

Description

PA1-25969 detects GSK3 alpha from human samples. PA1-25969 has been successfully used in Western blot procedures. The PA1-25969 immunogen is a synthetic peptide corresponding to the internal sequence residues 89-100 of human GSK3 alpha.

Glycogen synthase kinase-3 (GSK3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3’s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C-terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, GSK3 alpha and GSK3 beta, and they are strictly regulated via phosphorylation. Phosphorylation of GSK3beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer’s disease.
Specifications

Specifications

GSK3 alpha
Polyclonal
PBS with 0.02% sodium azide
P49840, Q2NL51, P18265
Glycogen Synthase Kinase Alpha, DKFZp686D0638
Chicken
IgY
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
2931, 50686, 606496
ELISA, Western Blot
Unconjugated
GSK3A
Liquid
GSK3A
Synthetic peptide corresponding to the internal sequence residues 89-100 of human GSK3 alpha.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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